An Interactive Jmol Tutorial about hydrophilic domain of complex I from Thermus Thermophilus:

* Complex I is one of the largest membrane proteins in the cell.

* The structure of complex I in prokaryotic contains 14 subunits, has L shaped structure with mixture of a helices, beta strands and loops, is classified into 2 domains, hydrophilic domain is termed by peripheral arm, and hydrophobic domain which is termed by membrane domain. The peripheral arm structure solved at 3.3 angstrom.

* Mutations in Complex I genes in humans lead to vision loss, brain dysfunction, or loss of muscle function, and such disorders are commonly due to the poor assembly of Complex I.

Overall structure Page 1
NADH and FMN binding Page 2
Stability and Mutations Page 3
Complex I activity Page 4
Interface between peripheral arm and membrane domain Page 5